Journal article
Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
E Scarr, TF Cowie, S Kanellakis, S Sundram, C Pantelis, B Dean
Molecular Psychiatry | Published : 2009
DOI: 10.1038/mp.2008.28
Abstract
Schizophrenia is widely acknowledged as being a syndrome, consisting of an undefined number of diseases probably with differing pathologies. Although studying a syndrome makes the identification of an underlying pathology more difficult; neuroimaging, neuropsychopharmacological and post-mortem brain studies all implicate muscarinic acetylcholine receptors (CHRM) in the pathology of the disorder. We have established that the CHRM1 is selectively decreased in the dorsolateral prefrontal cortex of subjects with schizophrenia. To expand this finding, we wanted to ascertain whether decreased cortical CHRMs might (1) define a subgroup of schizophrenia and/or (2) be related to CHRM1 genotype. We as..
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Grants
Awarded by National Alliance for Research on Schizophrenia and Depression
Funding Acknowledgements
We thank Mrs Jacyln Bartlett, Ms Suzette Sheppard and Mr Geoff Pavey for technical assistance; Dr Kenneth Opeskin, Ms Christine Hill, Professor Nick Keks and Professor David Copolov contributed towards collecting the tissue and clinical information relating to this study.This study was supported in part by grants-in-aid from the National Health and Medical Research Council (Project Grant no. 350344), The Rebecca L Cooper Medical Research Foundation and the Wood's Family Research Program. ES was the Ronald Philip Griffiths Research Fellow and the recipient of a NARSAD 2005 Young Investigator award, She is now the Royce Abbey Post-Doctoral Fellow. BD is an NH&MRC Senior Research Fellow (no.; 400016).